Research Progress on the Relationship between Acute Pancreatitis and the NLRP3 Inflammasome and the Regulatory Effects of Traditional Chinese Medicine
Year: 2026
Type: article
Abstract: 急性胰腺炎(Acute Pancreatitis, AP)作为一种临床常见的胰腺炎症性疾病，至今其发病机制依旧存在争议。以往研究发现胰腺腺泡细胞坏死和炎症反应与急性胰腺炎的严重程度及预后密切相关，且有众多机制与炎症反应存在相关性。近些年的深入研究发现，NLRP3炎症小体所启动的炎症级联反应与急性胰腺炎的发病机制密切相关。中药多成分、多靶点、多通路的优势，对急性胰腺炎的防治具有重要意义。文章综合近些年对NLRP3炎症小体激活机制的研究以及与该炎症小体相关的急性胰腺炎进展机制的研究，探讨中药通过干预上述机制对急性胰腺炎发挥的调控作用，就急性胰腺炎与NLRP3炎症小体的关系及中药调控的研究进展作一综述。Acute pancreatitis (AP), a clinically common inflammatory disease of the pancreas, continues to have a controversial pathogenesis. Previous studies have found that pancreatic acinar cell necrosis and inflammatory responses are closely related to the severity and prognosis of acute pancreatitis, with numerous mechanisms associated with the inflammatory response. Recent in-depth research has revealed that the inflammatory cascade initiated by the NLRP3 inflammasome is closely linked to the pathogenesis of acute pancreatitis. Traditional Chinese medicine (TCM), with its advantages of multi-component, multi-target, and multi-pathway actions, holds significant importance in the prevention and treatment of acute pancreatitis. This article synthesizes recent research on the activation mechanisms of the NLRP3 inflammasome and the progression mechanisms of acute pancreatitis related to this inflammasome, exploring the regulatory effects of TCM on acute pancreatitis through intervention in these mechanisms. It provides a review of the relationship between acute pancreatitis and the NLRP3 inflammasome, as well as the research progress in TCM regulation.
Author: 晓雅 季
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W7203604374