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Data from: Bioprinting collagenase-responsive hydrogel for controlled release of cowpea mosaic virus immunotherapy

Year: 2026
Type: dataset
Abstract: In this work, we developed a collagenase-responsive hydrogel system to covalently load cancer immunotherapy candidate cowpea mosaic virus (CPMV) using 3D digital light processing bioprinting technology. CPMV was functionalized with norbornene groups (CPMV-NB), which was then bioprinted into hydrogels with 8-arm polyethylene glycol norbornene and a collagenase-cleavable peptide via photoinduced thiol-ene click chemistry. This strategy enabled stable retention of CPMV-NB within the hydrogels and achieved controlled release of CPMV-NB triggered by collagenase. Furthermore, released CPMV-NB retained its immunogenicity to stimulate immune cells.
Source: DRYAD
DOI: 10.5061/dryad.msbcc2gcp
Authors: Zhao, Zhongchao, Xiang, Yi, Wu, Zhuohong, Sun, Yazhi, Schimelman, Jacob, Fiering, Steven, Chen, Shaochen, Steinmetz, Nicole, Aagard, Marnie
Institutions: University of California San Diego, University of California, Davis, Dartmouth College, Dartmouth Health, Dartmouth Cancer Center, Moores Cancer Center
Language: English
Open Access status: green
OpenAlex ID: W7203606264
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