Work

Cobalt‐Catalyzed C(sp 3 )H Carbonylation Enabled by Mo(CO) 6

Year: 2026

Type: article

Abstract: The carbonylation of unactivated C(sp 3 )H bonds represents an attractive strategy for the synthesis of valuable carbonyl‐containing compounds. Herein, we report a cobalt‐catalyzed 8‐aminoquinoline‐directed carbonylative C(sp 3 )H cyclization of aliphatic amides using Mo(CO) 6 as a practical solid CO surrogate. This atom‐economical protocol provides straightforward access to substituted succinimides in good‐to‐excellent yields, employing low cobalt catalyst loadings (5 mol%). The reaction proceeds under operationally simple conditions and avoids the direct handling of gaseous carbon monoxide. To the best of our knowledge, this study represents the first example of a cobalt‐catalyzed C(sp 3 )H carbonylative transformation using Mo(CO) 6 as the carbon monoxide source.

Source: European Journal of Organic Chemistry

DOI: 10.1002/ejoc.70744

Authors: Emma Duro, Inés Alonso, Juan Carlos Carretero, Nuria Rodríguez, Javier Adrio

Institutions: Universidad Autónoma de Madrid, ORFEO-CINQA Research Network

Language: English

Topic: Catalytic C–H Functionalization Methods

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $4,330

Funder: Ministerio de Ciencia, Innovación y Universidades