Work

Copper-Catalyzed, Photoinduced Carbonylative Cross-Coupling of Alkyl Iodides with Amines, Alcohols, and Sodium Hydroxide

Year: 2026

Type: article

Abstract: A general photoinduced copper-catalyzed carbonylative cross-coupling of alkyl iodides with amines for the synthesis of amides under mild conditions has been reported. Using a readily accessible, inexpensive copper complex, [Cu(bcp)DPEphos]PF6, the reaction proceeds at room temperature and accommodates a broad range of amines. Notably, the transformation can also be performed under ambient carbon monoxide pressure and can be extended to hydrazines, alcohols, and sodium hydroxide.

Source: Organic Letters

DOI: 10.1021/acs.orglett.6c03420

Authors: Omaïma Adaoudi, Julie Le Bescont, Antoine Bruneau-Voisine, Alexandre Le Flohic, Gwilherm Evano

Institution: Université Libre de Bruxelles

Language: English

Topic: Catalytic Cross-Coupling Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funders: Fonds De La Recherche Scientifique - FNRS, Fonds pour la Formation à la Recherche dans l’Industrie et dans l’Agriculture

Award: G7880416101