Work

Rhodanine and 2,4-dioxothiazolidine-based amides: synthesis and evaluation as dual-action cholinesterase inhibitors and antioxidants

Year: 2026

Type: article

Abstract: = 2.91 μM), which is also one of the most potent AChE inhibitors in this series. It acts as a specific, reversible, and competitive inhibitor of both BChE and AChE. Polyhalogenated analogues consistently outperformed their mono- and di-substituted counterparts, highlighting the critical role of lipophilic electron-withdrawing substituents. Within this series, rhodanines were generally preferred over thiazolidine-2,4-diones. Our results have demonstrated that rational modifications of the rhodanine and thiazolidine-2,4-dione cores support further investigation of selected derivatives as multitarget cholinesterase inhibitors with complementary antioxidant properties.

Source: RSC Medicinal Chemistry

DOI: 10.1039/d6md00502k

Authors: Enikő Šikorová, Adéla Kyslíková, Markéta Švarcová, Jiří Palarčík, Šárka Štěpánková, Martin Krátký

Institutions: Charles University, University of Pardubice

Language: English

Topic: Cholinesterase and Neurodegenerative Diseases

Subfield: Pharmacology (medical)

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funder: Univerzita Karlova v Praze