Work

Palmatine Induces TNNT1 Ubiquitination and Degradation to Potentiate Ferroptosis Sensitivity in Hepatocellular Carcinoma

Year: 2026

Type: article

Abstract: Background and Aims: Ferroptosis, an iron-dependent form of regulated cell death, serves as an important mechanism associated with cancer progression. Natural compounds, particularly alkaloids, have emerged as attractive candidates for regulating ferroptotic cell death, thereby providing a promising anticancer strategy. However, the molecular mechanisms underlying their antitumor effects remain poorly understood. In this study, we aimed to investigate the antitumor effects and underlying mechanisms of natural alkaloids against hepatocellular carcinoma (HCC). Methods: animal experiments was performed to explore the biological roles and molecular mechanisms of the lead compound. Results: animal models further confirmed that PAL suppressed tumor growth by downregulating TNNT1, with a favorable safety profile. Conclusions: This study reveals a previously unrecognized role of PAL as a ferroptosis sensitizer and highlights its translational potential for anti-HCC therapy.

Source: Journal of Clinical and Translational Hepatology

DOI: 10.14218/jcth.2026.00215