Work

Urinary UDP-sugars provide actionable prediction of acute kidney injury in cardiac surgery patients

Year: 2026

Type: article

Study design: Observational Study

Abstract: Acute kidney injury (AKI) is common in patients with open-heart surgery, but early diagnostics and therapies are limited. This study identifies a proinflammatory pathway activated during cardiopulmonary bypass. UDP-sugars are ligands of the P2Y14 receptor that appear during surgery in the urine of patients with AKI, predicting its onset. Patients with elevated UDP-sugars exhibited higher urinary inflammatory markers. Thus, the UDP-sugar/P2Y14 axis may serve as an early predictor and therapeutic target for cardiac surgery-related AKI.

Source: American Journal of Physiology-Heart and Circulatory Physiology

DOI: 10.1152/ajpheart.00233.2026

Authors: Christine Légaré, Patrick Caron, Mohammad M. Al-Bataineh, Aisha Ford, David R. Emlet, Jessica Deslauriers, Dennis Brown, Chantal Guillemette, Siamak Mohammadi, Sylvie Breton

Institutions: Université Laval, Centre de recherche du CHU de Québec-Université Laval, University of Pittsburgh, Harvard University, Massachusetts General Hospital

Language: English

Topic: Acute Kidney Injury Research

Subfield: Nephrology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: Université Laval, Canada Research Chairs, National Institutes of Health, Institut universitaire de cardiologie et de pneumologie de Québec, Université Laval, Canadian Institutes of Health Research

Awards: G2052997758, Elucidating the role of the pro-inflammatory P2Y14 receptor in acute kidney injury, Defining protein:protein interactions for the regulation of renal V-ATPase function: role in expression, assembly and trafficking., G5034718979, G6252601179, G9000067082, Role of MUC1 in the host defense against urinary tract infection, G957157629

OpenAlex ID: W7203677267

FWCI:

Cites: 84

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