Work

Serum hyaluronic acid as an early indicator of disease severity in transient abnormal myelopoiesis associated with Down syndrome

Year: 2026

Type: article

Abstract: Transient abnormal myeloproliferative syndrome (TAM) is a neonatal preleumatic syndrome that affects approximately 5–10% of newborns with Down syndrome. Most affected infants recover spontaneously, whereas approximately 20% develop severe disease with progressive cytopenia and multiple organ dysfunction [ 1 ]. These severe manifestations are associated with extreme leukocytosis, abnormal or immature immune responses, and severe liver dysfunction characterized by hypoalbuminemia, hyperbilirubinemia, or coagulopathy [ 2 ]. Because leukemogenesis originates from hematopoietic precursor cells within the fetal liver, abnormal hematopoiesis disrupts the hepatic microenvironment, causing hepatic dysfunction that contributes to disease severity. Hence, we assessed liver-related biomarkers measurable at diagnosis to determine patients at high risk of critical outcomes associated with TAM.

Source: Journal of Perinatology

DOI: 10.1038/s41372-026-02877-6

Authors: Eriko Eto, Masanori Inoue, Hironori Goto, Naoki Hirano, Tomoki Maeda, Kenji Ihara

Institution: Oita University

Language: English

Topic: Acute Myeloid Leukemia Research

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,790