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Why do we still give prophylactic topical antibiotics after intravitreal injections?

Year: 2026
Type: article
Abstract: Intravitreal anti-vascular endothelial growth factor (anti-VEGF) injections are among the most frequently performed procedures in modern medicine, with millions administered annually worldwide. Although post-injection infectious endophthalmitis is a devastating complication, its incidence remains exceptionally low (approximately 0.02–0.05%). Nevertheless, topical antibiotics continue to be prescribed routinely by many clinicians despite an overwhelming body of evidence demonstrating no protective benefit. This disconnect raises an important question: why do we continue prescribing a treatment that appears ineffective, costly, and potentially harmful?
Source: Eye
Language: English
Subfield: Ophthalmology
Field: Medicine
Open Access status: hybrid
Estimated APC paid: $3,590
OpenAlex ID: W7203679717
FWCI:
Cites: 10
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