Work

Rapid Synthesis of Weinreb Amides via Titanium‐Mediated Direct Amidation at Room Temperature

Year: 2026

Type: article

Abstract: Reported herein is a mild, rapid, and operationally simple protocol for the direct synthesis of N ‐methoxy‐ N ‐methylamides (Weinreb amides) from carboxylic acids in the presence of TiCl 4 . The reaction proceeds under ambient conditions, overcoming the challenges encountered by existing amidation methodologies. The protocol accommodates a broad range of substrates, delivering both aliphatic and aromatic Weinreb amides in good to excellent yields. Notably, the simple workup procedure eliminates the need for column chromatography, further enhancing the practical appeal.

Source: European Journal of Organic Chemistry

DOI: 10.1002/ejoc.70788

Authors: Aman G. Singh, Henry J. Hamann, P. Veeraraghavan Ramachandran

Institution: Purdue University West Lafayette

Language: English

Topic: Chemical Synthesis and Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $4,330

Funder: Herbert C. Brown Center for Borane Research, Purdue University