Rome V global epidemiology and validation survey: prevalence of disorders of gut–brain interaction and comparison with the Rome IV global epidemiology study
Year: 2026
Type: article
Study design: Observational Study
Abstract: BACKGROUND: The recently published Rome V adult diagnostic criteria facilitated an updated epidemiological survey of disorders of gut-brain interaction (DGBI). OBJECTIVE: We aimed to describe the global epidemiology of DGBI using the Rome V criteria and compare it with the Rome IV Rome Foundation Global Epidemiology Study. METHODS: A population-based Internet survey of 28,771 adults was conducted in 15 countries using the Rome V diagnostic questionnaire. DGBI prevalence was determined and compared with the Rome IV data. Multivariable logistic regression models were used to examine associations of demographic factors to Rome V DGBI status in the global population and to assess potentially associated clinical factors. RESULTS: The surveys yielded similar results. The prevalence of at least one DGBI using the Rome V criteria was 40.9%, compared with 40.5% for Rome IV. In both, the prevalence was higher among females and decreased with increasing age. In the Rome V sample (25 DGBI), the most prevalent oesophageal disorder was functional dysphagia at 4.1%, the most prevalent gastroduodenal disorder was functional dyspepsia at 8.1%, unclassified bowel disorder was the most prevalent bowel disorder (9.6%), followed by chronic constipation (8.9%) and IBS (8.5%) and proctalgia fugax was the most prevalent anorectal disorder (7.3%). The prevalence rates for two new DGBI were 5.1% for abdominal migraine and 1.4% for inability to belch syndrome. CONCLUSION: The Rome V global prevalence of DGBI is consistent with Rome IV. This bolsters confidence in the validity of prevalence rates for DGBI and reaffirms their high global burden.
Source: Gut
Authors: Ami D Sperber, Johann P Hreinsson, Magnus Simrén, Douglas A Drossman, Viola Andresen, Serhat Bor, Dan L Dumitrascu, Xiucai Fang, Guijun Fei, Luis Bustos Fernandez, Carlos Francesconi, Shin Fukudo, Sang Kil Lee, Chloé Melchior, Agata Mulak, Anne F Peery, David M Rodrigues, Javier Santos, Max Schmulson, Dipesh H Vasant, Jan Tack, Tiffany Taft, Olafur S Palsson
Institutions: Ben-Gurion University of the Negev, Sahlgrenska University Hospital, University of Gothenburg, University of North Carolina at Chapel Hill, Ege University, Iuliu Hațieganu University of Medicine and Pharmacy, Chinese Academy of Medical Sciences & Peking Union Medical College, Peking Union Medical College Hospital, Centro Médico Bustos Fernandez, Hospital de Clínicas de Porto Alegre, Tohoku University, Yonsei University, Yonsei University Health System, Inserm, Centre Hospitalier Universitaire de Rouen, University of Wrocław, Wroclaw Medical University, Queen's University, Vall d'Hebron Hospital Universitari, Universidad Nacional Autónoma de México, University of Manchester, KU Leuven, Rome Foundation
Language: English
Subfield: Gastroenterology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W7203686505