Work

Supplementary Material_Figures_and_FigureLegends.docx

Year: 2026

Type: supplementary-materials

Abstract: Insulin deficiency, as occurs in type 1 diabetes and advanced stages of type 2 diabetes, remains a major medical challenge because current insulin-based therapies do not fully restore metabolic homeostasis and can cause severe hypoglycemia. This paper shows that insulin deficiency profoundly remodels hepatic mRNA translation, globally suppressing protein synthesis while selectively activating metabolic pathways. Using ribosome profiling and functional studies, we identify regenerating islet-derived protein 3α (REG3A) as a leptin-responsive hepatic factor that improves hyperglycemia independently of insulin signaling. These findings identify translational control as an adaptive layer of metabolic regulation in insulin deficiency and reveal a potential insulin-independent pathway for improving glucose homeostasis.

Source: Figshare

DOI: 10.6084/m9.figshare.33265221

Authors: Pryscila Teixeira, Sarah Vincent, Romane Meurs, Gloria Ursino, Szabolcs Zahoran, Giulia Lucibello, Marcella Authiat, Anne-Claude Gavin, Giorgio Ramadori, Roberto Coppari

Topic: Pancreatic function and diabetes

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

Awards: To determine the role of FKBP10 in cancer, To elucidate the pathways improving metabolism in insulin deficiency, To elucidate the pathways promoting survival in insulin deficiency

OpenAlex ID: W7203687302

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