Year: 2026
Type: article
Study design: Case Report
Abstract: The Kp a antigen is a low-frequency Kell blood group antigen that is extremely rare in Koreans.Anti-Kp a cannot be detected by routine irregular antibody screening but might be associated with hemolytic transfusion reactions and hemolytic disease of the fetus and newborn.This paper reports a 53-year-old woman in whom anti-Kp a was identified together with anti-Le a during preoperative testing for cervical adenocarcinoma in situ.In the antibody identification test, reactivity with a Kp a -positive reagent red cell was observed at the antiglobulin phase, whereas the reaction was absent or weakened with enzyme-treated cells, showing an atypical serologic pattern.This case shows that antibodies against low-frequency antigens may be missed by routine screening and highlights the importance of the careful interpretation of reactivity with low-frequency antigen-positive reagent cells during antibody identification.(Korean J Blood Transfus 2026;37:96-101)
Authors: Soon Sung Kwon, Sinyoung Kim
Institutions: Yonsei University, Yonsei University Health System
Language: English
Topic: Blood groups and transfusion
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W7203688360
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