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Quadratus Lumborum Block versus Thoracic Paravertebral Block for Postoperative Recovery Quality after Percutaneous Nephrolithotomy: A Randomized Noninferiority Trial

Year: 2026

Type: article

Study designs: Randomized Controlled Trial, Clinical Trial

Abstract: INTRODUCTION: We aimed to determine whether anterior quadratus lumborum block (QLB) at the lateral supra-arcuate ligament is noninferior to thoracic paravertebral block (TPVB) for postoperative recovery quality after percutaneous nephrolithotomy (PCNL). METHODS: A total of 72 adults (American Society of Anesthesiologists physical status I-II) undergoing elective unilateral PCNL were randomized to QLB (n = 36) or TPVB (n = 36). Before general anesthesia, patients received ultrasound-guided anterior QLB (0.5% ropivacaine, 30 mL) or TPVB (0.5% ropivacaine, 20 mL), with standardized multimodal analgesia including patient-controlled intravenous morphine. The primary outcome was the Quality of Recovery-15 (QoR-15) score at 24 h; noninferiority required the lower bound of the 95% confidence interval (CI) for the difference (QLB minus TPVB) to exceed the prespecified margin of -6 points in both the modified intention-to-treat and per-protocol populations. Secondary outcomes were pain intensity, morphine consumption, patient satisfaction, and adverse events. RESULTS: Median QoR-15 scores at 24 h were 124 (interquartile range [IQR], 118-128) for QLB and 122 (IQR, 117-125) for TPVB (median difference, 2; 95% CI, -1 to 5; p < 0.001 for noninferiority), robust at stricter margins and confirmed per protocol. In secondary and exploratory analyses, QLB prolonged time to first analgesia (from postanesthesia care unit [PACU] admission; restricted mean survival time difference, 7.9 h; 95% CI, 5.9 to 9.8; time-averaged hazard ratio, 0.18; 95% CI, 0.10 to 0.31; p < 0.001), reduced 24-h morphine consumption (-4 mg; 95% CI, -6 to 0; p = 0.035), and lowered pain area under the curve at rest (-10 cm·h; 95% CI, -15 to -4) and on movement (-15 cm·h; 95% CI, -22 to -8; both p < 0.001). Hypotension occurred in 4 of 35 patients (11%) with QLB versus 13 of 36 (36%) with TPVB (relative risk, 0.32; 95% CI, 0.11 to 0.88; p = 0.015). CONCLUSIONS: Anterior QLB was noninferior to TPVB for postoperative recovery quality after PCNL. Associated reductions in pain and opioid use, and a lower observed incidence of hypotension, seen in secondary and exploratory analyses, are hypothesis-generating and warrant confirmation. Graphical abstract available for this article. TRIAL REGISTRATION: Chinese Clinical Trial Registry, ChiCTR2100044431.

Source: Pain and Therapy

DOI: 10.1007/s40122-026-00882-3