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Atypical Lentiginous Melanocytic Proliferations Case Series: Relationship to Type II Dysplastic Nevi and Lentiginous Melanoma

Year: 2026

Type: article

Abstract: A recent study described a distinctive subset of dysplastic nevi in older patients, genetically characterized by non-BRAFV600E driver mutations and frequent TERT promoter mutations. It has been proposed that these lesions overlap with the so-called lentiginous dysplastic nevi of the elderly. We explore this relationship in a series of 24 atypical lentiginous melanocytic proliferations, correlating with ex vivo dermoscopy, as well as immunohistochemical and molecular findings. We also discuss the utility of the MPATH-Dx tool to improve consensus for such lesions.

Source: Journal of Cutaneous Pathology

DOI: 10.1111/cup.70198

Authors: Maged Daruish, Ella De Ryck, Laura Gadeyne, Julie Lemahieu, Siebe Loontiens, Joni Van Der Meulen, Marc Haspeslagh, Boris C. Bastian, Saleem Taibjee

Institutions: Dorset County Hospital NHS Foundation Trust, Dorset County Hospital, Ghent University, Ghent University Hospital, Cancer Research Institute Ghent, University of California, San Francisco, UCSF Helen Diller Family Comprehensive Cancer Center

Language: English

Topic: Cutaneous Melanoma Detection and Management

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W7203693764

FWCI:

Cites: 9

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