Work

The SATvac model of CD8+ T cell expansion and contraction phases considering memory and effector cell differentiation

Year: 2026

Type: article

Abstract: Primary immune responses induce CD8+ T cell responses characterized by activation via antigen presenting cells, expansion, differentiation into effector and memory phenotypes, and contraction resulting in long-term memory populations. In this study a mathematical stochastic agent-based model is developed to simulate all phases of the CD8+ T cell response following vaccination. Importantly, the model successfully captures the stochastic nature of T cell dynamics throughout the response. It predicts T cell population with high accuracy while addressing mouse-to-mouse variability, highlighting its robust predictive power. This predictive model aims to improve T cell vaccination strategies by both informing the biology of the T cell response and streamlining vaccine development.

Source: PLoS Computational Biology

DOI: 10.1371/journal.pcbi.1014702

Authors: Seyedeh Fatemeh Seyyedizadeh, David A. Christian, Thomas A. Adams

Institutions: McMaster University, University of Pennsylvania, Norwegian University of Science and Technology

Language: English

Topic: T-cell and B-cell Immunology

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,043