β1-Adrenergic antagonist monotherapy of male rabbits with ischemic HFrEF reverses sarcolemmal Na + -K + pump inhibition and reduces lung congestion
Year: 2026
Type: article
Abstract: β1AR antagonists are frequently the only guideline-directed treatment tolerated in heart failure with reduced ejection fraction (HFrEF), and they might be deleterious because raised cytosolic [Na + ] is harmful in HFrEF and β1AR agonists reportedly enhance myocyte Na + export. Here, an antagonist reversed reduced Na + -K + pump function of myocytes from noninfarcted myocardium in an ischemic model of HFrEF and improved pulmonary congestion, consistent with benefit of Na + export but not with widely reported β1AR agonist-induced export.
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W7203702351