Work

Data for β-alanine betaine and nAChRs in Ascaris

Year: 2026

Type: dataset

Abstract: This dataset contains raw calcium-imaging data from Ascaris suum intestine, electrophysiological recordings from muscle preparations, and C. elegans motility time-course data used to generate Figures 5–7 in the associated paper publication. Files: Excel (.xlsx) and CSV (.csv) tables with calcium responses, region counts, depolarization amplitudes, spike frequencies, and motility/paralysis assays.Methods: Fluo‑3AM imaging, perfusion/application protocols, intracellular recordings, and motility scoring.Analysis: Data processed in GraphPad Prism 9.0; results reported as mean ± SEM; statistical comparisons by t-tests.The purpose of the experiments was to identify chemical messengers in a representative nematode parasite, Ascaris suum, and subsequently identify novel receptors for the development of new antiparasitic drugs (anthelmintics). We found a novel chemical messenger β‑alanine betaine suggesting that different acetylcholine receptors (ACR-23) could be novel and useful drug target sites.

Source: DataShare: the Open Data Repository of Iowa State University

DOI: 10.25380/iastate.32806229

Authors: Paul D. E. Williams, David J. Borts, Dongjie Liu, Jacob Byerley-Duke, Brett VanVeller, Richard J. Martin

Language: English

Topic: Nicotinic Acetylcholine Receptors Study

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funder: National Institute of Allergy and Infectious Diseases

Awards: Slo-1K channels, TRP-2 channels, emodepside and diethylcarbamazine in Filaria, Pharmacological Diversity of nAChRs in Clade III Nematodes: Brugia malayi

OpenAlex ID: W7203710302

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