Work

Metallaphotoredox Decarboxylative Cross‐Nucleophile Coupling of Diaryl Hydrazines via Hydrogen Evolution

Year: 2026

Type: article

Abstract: A visible light‐driven cross‐nucleophile coupling strategy for the synthesis of acyl hydrazides is reported. In contrast to conventional acylation methods, this approach merges diaryl hydrazines and α‐oxo acids through a dehydrogenative and decarboxylative metallaphotoredox process. An azobenzene intermediate is generated in situ and is intercepted by acyl radicals formed through decarboxylation. The transformation is enabled by a photostable pyrylium photocatalyst in combination with a cobaloxime cocatalyst under mild conditions, without external oxidants, producing only CO 2 and H 2 as byproducts. A broad range of substrates is tolerated, providing acyl hydrazides in moderate to high yields.

Source: ChemPhotoChem

DOI: 10.1002/cptc.70244

Authors: Joshua F. Cudjoe, Sandhya V. Poojari, Jon A. Tunge

Institution: University of Kansas

Language: English

Topic: Radical Photochemical Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $4,030

Funder: National Science Foundation