European Standard Clinical Practice Recommendations for Olfactory Neuroblastoma in Children and Adolescents: An Updated Consensus by the Expert Group
Year: 2026
Type: article
Abstract: Pediatric very rare tumors (VRTs) are a highly heterogeneous group of neoplasms defined by an annual incidence of <2 cases per million children under 18 years. Their rarity precludes prospective clinical trials, resulting in limited evidence-based guidelines and largely individualized treatment approaches. Olfactory neuroblastoma (ON) is an exceptionally rare pediatric VRT arising from the olfactory neuroepithelium, typically affecting adults. In children, ON is locally aggressive and may present with regional or distant metastases. Prognosis depends on stage, histology, and multimodal treatment. Owing to the absence of pediatric-specific guidelines, this project aims to develop internationally harmonized consensus recommendations for diagnosis and management.
Source: Pediatric Blood & Cancer
Authors: Daniela Di Carlo, Giulia Fichera, Benoit Dumont, Enrico Pozzo, Beate Timmermann, Romain Luscan, Antoine Moya‐Plana, Anna Synakiewicz, Ewa Bien, Malgorzata A. Krawczyk, Nuno Jorge do Reis Farinha, Rita Alaggio, Apostolos Pourtsidis, Brice Fresneau, Yves Reguerre, Tal Ben‐Ami, Calogero Virgone, Jelena Roganovic, Jan Godzinski, Ines Brecht, Dominik T. Schneider, Andrea Ferrari, Barbara Hero, Rajkumar Venkatramani, Elisabetta Zanoletti, Marco Ferrari, Daniel Orbach, Gianni Bisogno
Institutions: University of Padua, Azienda Ospedale - Università Padova, Centre Léon Bérard, Istituto Oncologico Veneto, Essen University Hospital, Deutsches Konsortium für Translationale Krebsforschung, Hôpital Necker-Enfants Malades, Institut Gustave Roussy, Gdańsk Medical University, University Children's Hospital Tübingen, Hospital de São João, Bambino Gesù Children's Hospital, Kaplan Medical Center, Children's Hospital Zagreb, Szpital im Tadeusza Marciniaka, University of Tübingen, Klinikum Dortmund, Fondazione IRCCS Istituto Nazionale dei Tumori, University of Cologne, Baylor College of Medicine, Texas Children's Hospital, Université Paris Sciences et Lettres, Institut Curie
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Funder: European Commission
Award: G7799207878
OpenAlex ID: W7203713024