Prognostic Impact of Sequential Measurable Residual Disease and KIT Variant Status in Pediatric Core-Binding Factor Acute Myeloid Leukemia: A Retrospective Multicenter Study of the Taiwan Pediatric Oncology Group
Year: 2026
Type: article
Study design: Observational Study
Abstract: Background: variants in pediatric CBF-AML. Methods: We retrospectively analyzed 112 children with CBF-AML. We assessed MRD in bone marrow samples collected at diagnosis, the end of induction (EOI), the end of second consolidation (EO2C), and the end of consolidation (EOC) using quantitative reverse transcription PCR with TaqMan assays targeting two fusion transcripts. Results: variant, those who achieved MRD of ≥ 4-LR at EOC had significantly more favorable outcomes. Conclusions: variant status with MRD assessment provides additional prognostic value during treatment.
Source: Annals of Laboratory Medicine
Institutions: Chang Gung Children's Hospital, Changhua Christian Hospital, Chang Gung Memorial Hospital, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung Medical University, Kaohsiung Medical University Chung-Ho Memorial Hospital, Taichung Veterans General Hospital, Hualien Tzu Chi Medical Center, Linkou Chang Gung Memorial Hospital, Chang Gung University
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
Funder: Ministry of Health and Welfare
Awards: G9001171846, G9001174682, G9001175223
OpenAlex ID: W7203715698