Year: 2026
Type: article
Study design: Observational Study
Abstract: A substantial proportion of critical illness survivors experience circadian disruptions following intensive care unit (ICU) discharge. However, the long-term circadian function in these patients remains poorly understood. This study aimed to characterize the circadian health of ICU survivors over a 24 month follow-up. Patients admitted to the ICU due to SARS-CoV-2 infection were recruited, and rest–activity rhythms (7-day actigraphy), mental health (Hospital Anxiety and Depression Scale), quality of life (12-item Short Form Survey), and respiratory function (spirometry) were assessed at short-term follow-up and at 24 months. The main analysis included 52 patients (65.4% male) with a mean (SD) age of 59.2 (8.27) years. The cohort showed a mean (95% CI) increase in circadian function index (CFI) of 0.06 (0.03–0.09). Participants were categorized into two groups: those without and those with a clinically meaningful improvement, defined as a ≥ 10% increase in CFI. Improvements in CFI correlated with changes in DLCO (rrm = 0.31; 0.04–0.54) and FEV 1 (0.43; 0.17–0.63). Longer duration of invasive mechanical ventilation was associated with lower CFI at 24 months (effect size = –0.338; –0.637 to –0.038). These findings indicate that while some survivors show circadian recovery over 24 months, others exhibit persistent alterations, supporting circadian-focused strategies in post-ICU rehabilitation.
Source: Scientific Reports
Authors: Mario Henríquez-Beltrán, Iván D. Benítez, Rafaela Vaca, Olga Minguez, Anna Galan-Gonzalez, Maria Aguilà, Sally Santisteve, Anna Vila, Sulamita Carvalho-Brugger, Paula González, Teresa Farre, Paula Rodríguez Ibañez, Carlota Regany, Monica Raluy, Nuria Forns, Carlos Rodríguez-Muñoz, Anna Moncusí-Moix, Anna Sánchez-Cucó, Nerea Ramirez Seco, Jesús Caballero, Carme Barberà, Gerard Torres, Jordi de Batlle, Gonzalo Labarca, Antoni Torres, David de Gonzalo-Calvo, Ferran Barbé, Jessica González, Adriano D. S. Targa
Institutions: Instituto de Salud Carlos III, Hospital Universitari Arnau de Vilanova, Centro de Investigación Biomédica en Red de Enfermedades Respiratorias, Centro de Investigación Biomédica en Red, Universidad Adventista de Chile, Instituto de Investigación Biomédica de Lleida, Hospital Universitari de Santa Maria, Pontificia Universidad Católica de Chile, Hospital Clínic de Barcelona, Consorci Institut D'Investigacions Biomediques August Pi I Sunyer, Universitat de Barcelona
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,690
Awards: G1638103087, Alteraciones en la salud del sueño y los ritmos circadianos tras una enfermedad critica: del diagnóstico a la predicción (CRONOCRIT), G3261301604, G3975241840, G4111366721, Hacia la Comprensión y el Diagnóstico de las Secuelas Pulmonares Persistentes en el Paciente Crítico: Introduciendo el Concepto de Endotipo (proyecto e-postcritical), G4387905368, G4513544132, G5834345604, G7006626996, G7439771857, G7647973106, Factores de riesgo, pronóstico personalizados y seguimiento a un año de los enfermos ingresados en las unidades de Cuidados Intensivos Españolas infectados por el virus COVID19: CIBERESUCICOVID
OpenAlex ID: W7203739191
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