Caenorhabditis Intervention Testing Program: all-trans retinoic acid lifespan extension in Caenorhabditis elegans requires 5-Fluoro-2'-deoxyuridine (FUdR)
Year: 2026
Type: article
Abstract: . While we observed that atRA extended lifespan across multiple genetic backgrounds, environmental factors may influence its efficacy. One such factor is 5-Fluoro-2'-deoxyuridine (FUdR), used to prevent progeny contamination in lifespan assays. Here, we show that FUdR enhances atRA's lifespan effects, but that this potentiation is not simply due to progeny elimination, as sterilization through auxin-mediated disruption of spermatogenesis does not potentiate atRA in lifespan extension. We conclude that atRA longevity is dependent on additional effects of FUdR that remain uncharacterized.
Source: PubMed
Language: English
Subfield: Aging
Domain: Life Sciences
Open Access status: green
Awards: Caenorhabditis Intervention Testing Program at Oregon, Caenorhabditis Genetics Center, Caenorhabditis Intervention Testing Program: Interventions That Modulate Health, Longevity and Aging Hallmarks, Caenorhabditis Testing Program Data Coordinating Center, Caenorhabditis Intervention Testing Program - Buck Institute
OpenAlex ID: W7203759490