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Ultrasound-assisted antifouling for continuous microfluidic manufacturing of RNA–LNP

Year: 2026

Type: article

Abstract: A back-pressure regulator integrated ultrasound device enables fouling-resistant, cavitation-free continuous microfluidic production of RNA–LNPs for over 6 h while preserving nanoparticle quality and delivery performance.

Source: Lab on a Chip

DOI: 10.1039/d6lc00340k

Authors: Yoon-Ho Hwang, Gijung Kim, Hoang Dinh, Minsoo Kim, Kathleen J. Stebe, Benjamin Davis, Daeyeon Lee, David Issadore

Institutions: University of Pennsylvania, Pukyong National University

Language: English

Topic: RNA Interference and Gene Delivery

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Funders: National Science Foundation, University of Pennsylvania, Pukyong National University, Busan Metropolitan City, Ministry of Science and ICT, South Korea

Awards: G1041201620, EFRI DCheM: Distributed Ribonucleic Acid (RNA) Manufacturing via Continuous Enzymatic Reaction and Separation in Biphasic Liquid Media, G2637524672, BioFoundry: Artificial Intelligence-Driven RNA BioFoundry, G8107547574, G8440189507

OpenAlex ID: W7203775814

FWCI:

Cites: 31

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