Work

Carboxyl-terminal blockade of sortilin binding enhances progranulin gene therapy in a mouse model of frontotemporal dementia

Year: 2026

Type: article

Source: Science Translational Medicine

DOI: 10.1126/scitranslmed.adr9158

Authors: Shreya N. Kashyap, Stephanie N. Fox, Vivianna R. DeNittis, Katherine I. Wilson, Nicholas R. Boyle, Mary Bullock, Aniketh S. Tadepalli, Stephanie R. Miller, Jorge J. Palop, Yohannes A. Ambaw, Tobias C. Walther, Robert V. Farese, Charles F. Murchison, Andrew E. Arrant, Erik D. Roberson

Institutions: University of Alabama at Birmingham, UAB Medicine, University of California, San Francisco, Memorial Sloan Kettering Cancer Center, Howard Hughes Medical Institute

Language: English

Topic: Amyotrophic Lateral Sclerosis Research

Subfield: Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: closed

Funders: Howard Hughes Medical Institute, National Institutes of Health, National Institute on Aging

Awards: UAB Alzheimer's Disease Research Center, G9000003862, G9000095383, Harnessing novel machine learning approaches for behavioral segmentation and brain signal integration in humanized models of Alzheimer's disease, Interneuron circadian rhythms and tau-dependent network excitability in Alzheimer's disease pathogenesis, Decoding the Multifactorial Etiology of Neural Network Dysfunction in Alzheimer's Disease

OpenAlex ID: W7203790332

FWCI:

Cites: 65

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