Year: 2026
Type: article
Abstract: Bioelectronic medicine enables direct interfacing with native cell populations but remains limited by poor long-term integration and minimal interaction with non-electroactive cells. In contrast, regenerative medicine promotes tissue integration yet lacks bidirectional functionality. Here, we present a hybrid implantation methodology combining a tissue engineered cellularized hydrogel with a neural recording array for simultaneous delivery into the brain via needle placement. This approach enables co-localized transplantation of cells and electronics while minimizing surgical footprint. Post-implantation electrophysiological recordings show functional integration with surrounding neural tissue, demonstrating the feasibility of this platform for coupled bioelectronic sensing and regenerative capabilities.
Source: MRS Communications
Language: English
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $3,390
Awards: G1828984001, Mechanisms that lie behind the pathology of Parkinson's Disease., G3676185368, MICA: Multi-parametric and super-resolution imaging of amyloidogenic proteins, Liquid droplets and hydrogels: protein phase transition in health and disease, G4163270928, Liquid droplets and hydrogels: protein phase transition in health and disease, Mixed Ionic and electronic Transport In Conjugated polymers for bioelectronicS, G87014449, High-density cortical implants for cognitive neuroscience and rehabilitation of speech using brain-computer interfaces.
OpenAlex ID: W7203791864