Low Body Weight and Long-Term Outcomes in Cancer-Associated Venous Thromboembolism ― From the COMMAND VTE Registry-2 ―
Year: 2026
Type: article
Abstract: BACKGROUND: Low body weight (BW) is reportedly associated with an increased risk of bleeding and mortality in venous thromboembolism (VTE). However, there are limited data on the impact of low BW on clinical outcomes among patients with cancer-associated VTE in the direct oral anticoagulants (DOACs) era. METHODS AND RESULTS: We analyzed 1,484 patients with symptomatic VTE and active cancer from the COMMAND VTE Registry-2, and divided the cohort into low (≤60 kg) and non-low (>60 kg) BW groups (n=969 and 515, respectively). The cumulative 3-year incidence of major bleeding was significantly higher in the low than non-low BW group (13.1% vs. 10.2%; Gray's P=0.04). However, after adjustment, the risk of major bleeding in the low BW was no longer significantly different to that in the non-low BW group (hazard ratio [HR] 1.36; 95% confidence interval [CI] 0.96-1.92). The cumulative 3-year incidence of recurrent VTE did not differ significantly between the low and non-low groups (5.2% vs. 5.4%, respectively; Gray's P=0.46; adjusted HR 0.71; 95% CI 0.42-1.18). The cumulative 3-year incidence of all-cause death was significantly higher in the low than non-low BW group (65.0% vs. 50.8%; log-rank P<0.001; adjusted HR 1.47; 95% CI 1.25-1.73). CONCLUSIONS: Low BW in cancer-associated VTE was not associated with major bleeding or recurrent VTE, but was associated with all-cause death, possibly reflecting cancer-related prognostic factors.
Source: Circulation Journal
Authors: Soichiro Kobayashi, Yoshito Ogihara, Yugo Yamashita, Takeshi Morimoto, Ryuki Chatani, Kazuhisa Kaneda, Yuji Nishimoto, Nobutaka Ikeda, Yohei Kobayashi, Satoshi Ikeda, Kitae Kim, Masayuki Shiba, Toru Takase, Shuhei Tsuji, Maki Oi, Takuma Takada, Kazunori Otsui, Jiro Sakamoto, Takeshi Inoue, Shunsuke Usami, Po-Min Chen, Kiyonori Togi, Norimichi Koitabashi, Seiichi Hiramori, Kosuke Doi, Hiroshi Mabuchi, Yoshiaki Tsuyuki, Koichiro Murata, Kensuke Takabayashi, Hisato Nakai, Daisuke Sueta, Wataru Shioyama, Tomohiro Dohke, Toru Sato, Ryusuke Nishikawa, Takeshi Kimura, Kaoru Dohi, on behalf of the COMMAND VTE Registry-2 Investigators
Institutions: Mie University, Kyoto University, Hyogo Medical University, Kurashiki Central Hospital, Toyonaka Municipal Hospital, Toho University Ohashi Medical Center, Osaka Red Cross Hospital, Nagasaki University, Kobe City Medical Center General Hospital, Kitano Hospital, Kindai University Hospital, Japanese Red Cross Society Wakayama Medical Center, Otsu Red Cross Hospital, Tokyo Women's Medical University, Institute of Advanced Biomedical Engineering and Science, Tokyo Women's Medical University, Kobe University Hospital, Tenri Hospital, Kansai Electric Power (Japan), Kansai Electric Power Hospital, Saiseikai Noe Hospital, Kindai University Nara Hospital, Kindai University, Gunma University, Kokura Memorial Hospital, Kyoto Medical Center, Koto Hospital, Koto Memorial Hospital, Shimada Municipal Hospital, Shizuoka City Hospital, Hirakata Kohsai Hospital, Sugita Genpaku Memorial Obama Municipal Hospital, Kumamoto University, Shiga University of Medical Science, Kohka Public Hospital
Language: English
Subfield: Internal Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W7203793878