Year: 2026
Type: article
Abstract: Heart failure is a leading cause of morbidity and mortality worldwide. Emerging evidence points to vascular dysfunction as a major contributor to the development and progression of this grievous syndrome. Functional interplay between the myocardium and vasculature involves endothelial cells, vascular smooth muscle cells, and pericytes governing tissue perfusion, vascular tone, inflammation, and metabolism. Vascular cells play a central role in maintaining cardiovascular homeostasis by sensing hemodynamic and inflammatory stimuli and releasing vasoactive and paracrine factors. Dysregulation of endothelium-derived mediators such as NO, endothelin-1, and endothelium-derived hyperpolarizing factors, along with vascular oxidative stress, inflammation, and vascular remodeling (eg, disturbances in angiogenesis and microvascular rarefaction) impair myocardial perfusion and can accelerate heart failure progression. Here, we summarize key molecular mechanisms linking vascular dysfunction to heart failure, emphasizing endothelial signaling, oxidative stress, inflammation, and angiogenic remodeling.
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: Mechanisms of obesity-dependent alterations in cardiomyocyte metabolism, Cardiomyocyte bromodomain protein 4 (BRD4) in physiology and disease, Vevo F2 Ultrasound Imaging System, Molecular Mechanisms of HFpEF-associated Atrial Fibrillation, ETS2-dependent control in cardiomyocyte ischemia/reperfusion injury
OpenAlex ID: W7203819843