Work

A representative mechanistic model of multisolute transport in low-flow hollow-fiber dialyzers for wearable artificial kidney-oriented design

Year: 2026

Type: article

Abstract: clearance data from commercial low-flow dialyzers showed that the model captured the main clearance trends of representative solutes under selected operating conditions. Apparent resistance decomposition further suggested that, under the baseline condition and the present resistance definition, the apparent blood-side boundary-layer fraction increased with solute size, whereas the apparent intramembrane fraction decreased. Parametric analyses were further conducted to examine the effects of selected operating and geometric factors in this model. The proposed framework may support preliminary numerical screening and mechanistic interpretation of compact dialysis-module concepts under wearable artificial kidney-relevant low-flow conditions.

Source: Medical Engineering & Physics

DOI: 10.1088/1873-4030/ae9c3f

Authors: Jun Zhang, Haonan Zheng, Hongtao Zhang, Fengmin Shao, Xiaobo Rao

Institutions: Zhengzhou University, Henan Provincial People's Hospital, Zhengzhou People's Hospital

Language: English

Topic: Dialysis and Renal Disease Management

Subfield: Nephrology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,170