Work

The Arylation of α,β-Unsaturated Carbonyl Compounds by Arenediazonium Salts—A Synthetic Route to Precursors of Substituted 2-Mercaptothiazoles

Year: 2026

Type: article

Abstract: This paper presents the first examples of the use of arylation products of α,β-unsaturated carbonyl compounds under Meerwein reaction conditions for the synthesis of substituted 2-mercaptothiazoles. The method described here yields α-thiocyanatocarbonyl building blocks, which subsequently enable cyclization reactions with thiourea or mercaptoacetamides to synthesize the title compounds. In this way, 5-arylmethyl-2-mercaptothiazoles substituted at the 4-position and their S-substituted derivatives can be prepared very efficiently.

Source: Molecules

DOI: 10.3390/molecules31162908

Authors: Mary Y. Ostapiuk, Oksana V. Barabash, Mykola D. Obushak, Mykola Kravets, Andreas Schmidt, Yurii V. Ostapiuk

Institutions: Lviv University, Institute of Physical Chemistry, Polish Academy of Sciences, Clausthal University of Technology

Language: English

Topic: Sulfur-Based Synthesis Techniques

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $3,258

Funder: National Research Foundation of Ukraine