Inhibiting cyclin D1–CDK6 suppresses senescence-associated inflammatory gene expression and age-related functional decline
Year: 2026
Type: article
Source: Nature Aging
Authors: Adarsh Rajesh, Aaron P. Havas, Rouven Arnold, Kathryn Lande, Xue Lei, Kelly Yichen Li, Armin Gandhi, Ana Catarina Franco, Seung-Hwa Woo, Anthony B. Lagnado, Angela Liou, K. Garrett Evensen, Linshan Laux, Maggie Klaers, Jake Kircher, Amirhossein Nayeri Rad, Hiroshi Tanaka, Marcos Garcia Teneche, Michael Alcaraz, Karl N. Miller, Zoe Yao, Sviatlana Zaretski, Sainath Mamde, Qian Yang, Jessica Proulx, Andrew Davis, Laurence Haddadin, Carolina Cano Macip, Brightany Li, Nirmalya Dasgupta, Zong Ming Chua, Cedomir Stamenkovic, Gabriele Guarnaccia, Hideki Tanizawa, Charlene Miciano, Elizabeth Smoot, Allen Wang, Rebecca A. Porritt, Alessandra Sacco, Ken-ichi Noma, Jeffrey H. Albrecht, Laura J Niedernhofer, Joao F Passos, April E. Williams, Bing Ren, Kevin Y. Yip, Peter D. Adams
Institutions: Sanford Burnham Prebys Medical Discovery Institute, Cold Spring Harbor Laboratory, Cancer Center at Cold Spring Harbor Laboratory, Salk Institute for Biological Studies, Mayo Clinic, Rady Children's Hospital-San Diego, University of Minnesota, Ludwig Boltzmann Institute for Traumatology, The Research Center in Cooperation with AUVA, University of California San Diego, La Jolla Institute for Immunology, Baylor College of Medicine, Hokkaido University, Institute for Genetic Medicine, Hokkaido University, University of Oregon, New York Genome Center, Columbia University
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: closed
Awards: G1033967322, G1198413800, San Diego Nathan Shock Center, A Multidisciplinary Stem Cell Training Program at Sanford Burnham Prebys Institute, A Critical Component of the La Jolla Mesa Educational Network, Development of machine learning software to quantitatively map telomere induced senescence in tissue sections during aging, G680976502, G7453529570, Development of machine learning software to quantitatively map telomere induced senescence in tissue sections during aging, The role of sub-lethal mitochondrial apoptotic stress in cellular senescence, Investigating the role of cytosolic mitochondrial double-stranded RNA in cellular senescence and aging, Cancer Center Support Grant (CCSG), Aging as a Risk Factor and Target for Prevention of Liver Cancer
OpenAlex ID: W7203834746