Year: 2026
Type: article
Abstract: Native tissue crosstalk depends on spatial organization, temporal dynamics, and mechanical context, yet 2D cultures and stochastic organoids provide limited control over multicellular and matrix interfaces. This review categorizes biological crosstalk into intercellular, cell-extracellular, and intertissue communication and surveys biofabrication strategies that reconstruct these interactions. We propose a framework for designing physiologically relevant tissue models for mechanistic disease studies and therapeutic discovery.
Source: npj Biomedical Innovations.
Authors: Goeun Yoon, Jihwan Kim, Jinah Jang
Institution: Pohang University of Science and Technology
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $2,690
OpenAlex ID: W7203838427