A noninvasive 13 C-mannitol breath test to monitor semaglutide treatment-induced delayed oral-cecal transit in mice
Year: 2026
Type: article
Abstract: A novel noninvasive assay uses orally administered 13 C-mannitol, metabolized by cecal microbiota into exhaled 13 CO 2 , to enable continuous, longitudinal measurement of oral-cecal transit time in unanesthetized, freely moving mice via indirect calorimetry with isotope ratio analysis. Pharmacological validation confirmed sensitivity to delayed transit, including a pronounced semaglutide-induced delay in obese mice that models a clinically relevant glucagon-like peptide-1 (GLP-1) receptor agonist adverse effect.
Authors: Daniel E. Vieira, Emily M. Langmeyer, Marissa D. Cortopassi, William B. Rubio, Sarah N. Flier, Lynn Bry, Alexander S. Banks
Language: English
Subfield: Gastroenterology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W7203840129