Work

The Role of NLRP3 in Gouty Arthritis and the Beneficial Effects of Phytochemicals

Year: 2026

Type: article

Abstract: Gouty arthritis (GA) is a chronic inflammatory disease caused by the deposition of monosodium urate crystals, with a complex pathogenesis. Although current therapies can alleviate symptoms, they are often accompanied by considerable side effects. Phytochemicals, as natural bioactive compounds, have attracted increasing attention due to their diverse pharmacological activities and relatively low toxicity. Emerging evidence indicates that the NACHT, leucine-rich repeat, and pyrin domain-containing protein 3 (NLRP3) inflammasome plays a pivotal role in the inflammatory cascade of GA. Its excessive activation not only exacerbates joint inflammation but also contributes to tissue damage. This review aims to provide a systematic overview of the mechanisms by which the NLRP3 inflammasome participates in GA and to highlight the potential therapeutic applications of phytochemicals that modulate NLRP3 inflammasome activity, thereby offering a theoretical basis for the development of novel natural medicines.

Source: Pharmacognosy Magazine

DOI: 10.1177/09731296261476948

Authors: Shimei He, Tao Ye

Institution: China Three Gorges University

Language: English

Topic: Gout, Hyperuricemia, Uric Acid

Subfield: Nephrology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $1,600