Work

The multifaceted role of E3 ubiquitin ligase SMURF1 in cellular signaling and disease regulation

Year: 2026

Type: article

Abstract: ABSTRACT SMAD-specific E3 ubiquitin ligase 1 (SMURF1) is a key regulator of cellular processes through its role in ubiquitination and degradation of various substrate proteins. As a member of the NEDD4 family of E3 ubiquitin ligases, SMURF1 is involved in modulating critical signaling pathways which regulate cellular functions such as proliferation, differentiation, apoptosis, and autophagy. This review provides a comprehensive overview of the physiological regulation of SMURF1, its intricate regulatory networks, and its involvement in multiple diseases. The role of SMURF1 in maintaining cellular homeostasis is influenced by transcriptional, post-transcriptional, and post-translational mechanisms. The review highlights the biological regulation of SMURF1 and potential of targeting SMURF1 in precision medicine, proposing future research directions that focus on its molecular mechanisms and therapeutic applications.

Source: Cell Death and Disease

DOI: 10.1038/s41419-026-09218-7

Authors: Xinlei Wu, Kai Yang

Institutions: First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, Guangzhou Laboratory, Guangzhou Medical University

Language: English

Topic: Ubiquitin and proteasome pathways

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $4,990