Work

Targeting LKB1-inactivated lung cancers with a stapled peptide inhibitor of the CRTC-CREB pathway

Year: 2026

Type: article

Abstract: . Importantly, SAH-CBDs penetrate cells without causing membrane disruption, inhibit CREB-dependent transcription, and selectively suppress the growth of LKB1-null lung cancer cells, with minimal effects on LKB1-wild-type cells. These findings establish SAH-CBDs as a mechanistic tool and a prototype therapeutic for targeting a key transcriptional vulnerability in LKB1-inactivated NSCLC.

Source: Molecular Therapy Oncology

DOI: 10.1016/j.omton.2026.201331

Authors: Xin Zhou, Gregory H. Bird, Mu Yu, Jian-Liang Li, Xzaviar K. Solone, Michael C. Chung, Juan Guan, Loren D. Walensky, Lizi Wu

Institutions: University of Florida Health, University of Florida, UF Health Cancer Center, Dana-Farber Cancer Institute, National Institute of Environmental Health Sciences, The University of Texas at Austin

Language: English

Topic: Chemical Synthesis and Analysis

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,900

Funders: Florida Department of Health, National Cancer Center, National Institutes of Health, University of Florida Health, International Centre for Bamboo and Rattan, National Cancer Institute, National Institute of General Medical Sciences, National Institute of Dental and Craniofacial Research

Awards: Signaling and Targeting of CRTC1-MAML2 Fusion Oncoprotein in Salivary Gland, Mechanisms of Assembly and Functional Regulation in Non-canonical Biomolecular Condensates, Dissecting and Targeting Deregulated Mitochondrial Apoptosis in Human Cancer, Stapled Peptides for Protein Interaction Research and Therapeutic Targeting in Human Cancer

OpenAlex ID: W7203885554

FWCI:

Cites: 60

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Related to: 10