PKCα-deficient mice show altered synaptic signaling and impaired fear extinction
Year: 2026
Type: article
Abstract: mice showed impaired hippocampus-dependent spatial memory, increased anxiety-like behavior, and a marked deficit in contextual fear extinction. These findings identify PKCα as part of a signaling program associated with synaptic function and support a role for PKCα-dependent processes in adaptive updating of learned fear.
Source: Neurobiology of Stress
Authors: Lulu An, Miyoung Yang, Qi Ding, Hongbing Wang
Institution: Michigan State University
Language: English
Topic: Memory and Neural Mechanisms
Subfield: Cognitive Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $4,050
Award: G9000078966
OpenAlex ID: W7203885724