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A Repurposed S -Adenosyl- l -Methionine Synthetase Mediates Cytidyl–Cyclitol Natural Product Assembly

Year: 2026

Type: article

Source: Journal of the American Chemical Society

DOI: 10.1021/jacs.6c11487

Authors: Zhongtian Yu, Wenhe Zhang, Richiro Ushimaru, Keita Shigemi, Takahiro Mori, Takayoshi Awakawa, Koh Takeuchi, Ikuro Abe

Institutions: The University of Tokyo, Shenyang Pharmaceutical University, Kyushu University, Japan Science and Technology Agency, RIKEN Center for Sustainable Resource Science, RIKEN, National Sun Yat-sen University, University of Toyama

Language: English

Topic: Microbial Natural Products and Biosynthesis

Subfield: Pharmacology

Field: Medicine

Domain: Health Sciences

Open Access status: closed

Funders: Asahi Glass Foundation, Institute for Fermentation, Osaka, Japan Agency for Medical Research and Development, New Energy and Industrial Technology Development Organization, Daiichi Sankyo Foundation of Life Science, Nagase Science Technology Foundation, MSD Life Science Foundation, Public Interest Incorporated Foundation, JKA Foundation, Japan Society for the Promotion of Science, Japan Science and Technology Agency, Chemo-Sero-Therapeutic Research Institute

Awards: 新規リン酸アミド含有天然物の生合成経路の探索と解明, G1779040330, G1876344285, G381971090, アミノ酸代謝が鍵となる複雑骨格薬用天然物の新奇生合成マシナリー, G6233850887, タンパク質内ラジカルの精密制御に基づく革新的物質変換反応の開発, 薬用天然物の複雑骨格構築を担う新奇生合成酵素を用いた革新的次世代型天然物創薬, G8672242964, G8914533034

OpenAlex ID: W7203890249

FWCI:

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