Work

Alkoxyl Derivatives of 7-Hydroxyflavone: Synthesis, Physicochemical Properties, Antioxidant, and Antihyperglycemic Activities

Year: 2026

Type: article

Abstract: Flavones are natural substances widely distributed in fruits and vegetable. Their compounds are characterized by a broad spectrum of activities, including antioxidant activity. Their most interesting biological effect, however, is antihyperglycemic activity, mediated by the inhibition of α-glucosidase. A series of 7-hydroxyflavone derivatives was synthesized and comprehensively characterized using nuclear resonance magnetic spectroscopy. The biological potential of the synthesized derivatives was assessed through antioxidant (DPPH) and α-glucosidase inhibitory assays. The physicochemical and pharmacokinetic properties were analyzed using in silico methods. Finally, molecular docking studies were performed to elucidate the binding mode of compounds within the catalytic site of α-glucosidase.

Source: Applied Sciences

DOI: 10.3390/app16168331

Authors: Patryk Mruczek, Andrzej Grudzień, Monika Kadela-Tomanek

Institutions: Medical University of Silesia, Cracow University of Technology

Language: English

Topic: Synthesis of Organic Compounds

Subfield: Pharmacology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,896