Multi-level intervention on polysubstance use: A systematic scoping review protocol
Year: 2026
Type: preprint
Abstract: Polysubstance use, defined as the concurrent or simultaneous use of two or more substances, either intentionally or unintentionally, has become increasingly prevalent in the United States and is associated with elevated risks of overdose, infectious disease transmission, adverse health outcomes, and treatment challenges. Recent trends have highlighted the growing co-use of opioids, stimulants, benzodiazepines, alcohol, cannabis, nicotine, and emerging substances such as xylazine. Although a variety of interventions have been implemented to address substance use and related harms, evidence specific to adults who use multiple drug classes remains fragmented across disciplines and intervention levels.
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7203900270