Exploring the Role of Patient Preferences in Hepatocellular Carcinoma Treatment Decisions: A Qualitative Study
Year: 2026
Type: article
Abstract: Background. Hepatocellular carcinoma (HCC) treatment decisions are becoming increasingly complex as new treatment options emerge. Improved understanding of tradeoffs and patient preferences in treatment decisions will enhance patient–provider discussions, improve treatment development, and inform HCC treatment guidelines. We performed a qualitative study involving patients with HCC and medical providers to assess the role of patient preferences in HCC treatment choices. Methods. Patient participants included those with HCC seen within a single tertiary care center. Provider participants involved physicians and advanced practice providers who cared for patients with HCC from a single center. Baseline and posttreatment patient interviews were conducted by trained qualitative research experts, informed by semi-structured interview guides, and analyzed using thematic analysis with pilot-tested codebooks. Summaries included a narrative description of the themes and subthemes that emerged related to each code, and illustrative quotes were used to highlight each theme. Results. The baseline interview involved 30 patients with HCC (22 of whom participated in follow-up interviews) and 10 providers who cared for patients with HCC. Patients identified factors considered when making treatment decisions included provider confidence and experience, patient prior cancer experiences, other health issues, and faith. Providers primarily discussed the role of Barcelona Clinic Liver Cancer stage, liver function, performance status, and eligibility of liver transplantation in making treatment recommendations. There was general agreement among providers that there is a need to better understand the role of patient values to improve care for HCC. Limitations. Qualitative interviews were limited to patients and providers from a single center. Conclusions. This qualitative study provided information on the variety of values considered by both patients and providers in HCC treatment decisions and the importance of considering tradeoffs of efficacy, toxicity, and inconvenience/costs.
Source: UNC Libraries
DOI: 10.17615/t7e0-1e67
Authors: Lupu, Gabriel V., Sanoff, Hanna K., Schooler, Matthew, Waheed, Myra, Evon, Donna M., Barritt, A. Sidney, Shroff, Hersh, Somasundaram, Ashwin, Yanagihara, Ted K., Sanderford, Ariel E., Mauro, David M., Richardson, Daniel, Teal, Randall, Fix, Oren K., Phillips, Julia R., Moon, Andrew M., Shah, Neil D., Basch, Ethan, Carda-Auten, Jessica, Kappelman, Michael D., Sorah, Jonathan D., Wagner, Lynne I., Jia, Jingquan, Gerber, David A., Ekuban, Hiwot A., Triglianos, Tammy
Institution: University of North Carolina at Chapel Hill
Subfield: Hepatology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7203904636
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