Work

A parabolic correlation between stress hyperglycemia ratio and 28-day mortality in US participants with diabetes and heart failure

Year: 2026

Type: article

Abstract: Current research lacks sufficient insight into the correlation between the stress hyperglycemia ratio (SHR) and 28-day mortality in critically ill patients with heart failure and diabetes. Our study aims to investigate this correlation. A total of 1697 critically ill patients with heart failure and diabetes were enrolled from the Medical Information Mart for Intensive Care IV 3.1 database. Logistic regression, Cox proportional hazards modeling, and smooth curve fitting analyses were used to meet the research objectives. The total rate of 28-day mortality was 12.1%. Multiple regression analysis showed that the hazard ratios for 28-day mortality in the lowest (Q1), middle (Q3), and highest (Q4) SHR quartiles were 1.85 (95% confidence interval [CI] = 1.17-2.92), 1.38 (95% CI = 0.84-2.20), and 2.52 (95% CI = 1.61-3.93), respectively. Moreover, a U-shaped relationship was found between SHR and mortality risk, with the lowest risk at an SHR of 1.0. Above this level, the hazard ratio increased to 1.707 (95% CI = 1.143-2.549, P = .009). Subgroup analysis revealed no other significant findings (P > .05). In patients with heart failure and diabetes, SHR exhibits a parabolic association with 28-day all-cause mortality. Notably, an SHR value exceeding 1.0 is associated with a significantly increased risk of 28-day mortality.

Source: Medicine

DOI: 10.1097/md.0000000000050235

Authors: Qiaowen Huang, Yonggang Peng, Lifang Xiao, Shihan Zhang, Zhiwei Lu, Huan Lin

Institutions: Fujian Medical University, University of Florida Health, University of Florida

Language: English

Topic: Hyperglycemia and glycemic control in critically ill and hospitalized patients

Subfield: Endocrinology, Diabetes and Metabolism

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,950