How Does Sas5 Recognize Histone Proteins?
Year: 2026
Type: article
Abstract: Histones are proteins that help package DNA and carry chemical modifications involved in regulating DNA accessibility. This project investigated how the Sas5 YEATS domain recognizes histones and whether it uses the same binding mechanism as the related protein Taf14. Across multiple independent peptide-pulldown experiments, the F85A mutation strongly reduced histone binding by Taf14, while Sas5 retained histone binding after the equivalent mutation. These results suggest that Sas5 recognizes histones through a mechanism distinct from Taf14 and help define what makes Sas5 different from other YEATS-domain proteins.
Source: UNC Libraries
DOI: 10.17615/vt8g-1h07
Author: Wang, Ruizhe
Institution: University of North Carolina at Chapel Hill
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W7203907137
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