Large-scale proteomics to identify novel biomarkers linking social determinants of health to heart failure risk
Year: 2026
Type: article
Abstract: Adverse social determinants of health (SDOH) associate with greater heart failure (HF) risk. Among 9879 community-based participants of the Atherosclerosis Risk in Communities (ARIC) cohort study, we assessed 4955 plasma proteins using an aptamer-based platform (SomaLogic). We derived an SDOH factor comprising income, education, and area deprivation index (ADI) in Black and white participants. Proteins associated with this factor at Bonferroni significance were tested for associations with incident HF using multivariable Cox proportional hazard models. Among Black participants, 36 proteins were associated with both the SDOH factor and incident HF, 126 were among white participants, and 12 were shared between race strata. Eight of these demonstrated significant mediation effect in causal mediation models. Key results were replicated in 49,396 participants in UK Biobank. Mendelian randomization and colocalization suggested a potentially causal effect of C1q tumor necrosis factor-related protein 1 (C1QTNF1), an adiponectin paralog, on HF. We demonstrate protein biomarkers associated with SDOH burden and HF risk.
Source: Science Advances
Authors: Diego Ramonfaur, Rani Zierath, Yimin Yang, Victoria Lamberson, Brian Claggett, Tiffany M. Powell-Wiley, Tammy Leonard, Anna Kucharska-Newton, Keenan A. Walker, Patricia P. Chang, Nrupen Bhavsar, Ganga Bey, Kenneth Butler, Chiadi Ndumele, Josef Coresh, Bing Yu, James S. Floyd, Michelle C. Odden, Amil M. Shah
Institutions: Brigham and Women's Hospital, Cleveland Clinic, Pennsylvania State University, Harold C. Simmons Comprehensive Cancer Center, The University of Texas Southwestern Medical Center, National Institutes of Health, National Heart, Lung, and Blood Institute, University of North Carolina at Chapel Hill, National Institute on Aging, Duke University, Duke Medical Center, University of Mississippi Medical Center, Johns Hopkins University, NYU Langone Health, The University of Texas Health Science Center at Houston, University of Washington, Stanford Medicine, Stanford University
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $4,500
Awards: Profiling Cardiovascular Events and Biomarkers in the Very Old to Improve Personalized Approaches for the Prevention of Cardiac and Vascular Disease, Quantifying cardiac structure and function to define the progression to hear failure in African Americans, G9000013532, G9000016456, G9000025134, G9000231270, G9000299299, Proteomic signatures to identify pathways underlying the progression to heart failure
OpenAlex ID: W7203917283