Work

Opportunities and challenges for mRNA vaccines against tuberculosis

Year: 2026

Type: article

Abstract: Tuberculosis (TB) vaccine development remains challenging due to the complex biology of M. tuberculosis infection and the absence of established correlates of protection. mRNA platforms can induce strong systemic humoral and effector immunity and offer several potential advantages; however, limited lung-localised immunity may restrict current formulations. This Perspective examines these challenges and discusses strategies to optimise mRNA vaccine design, formulation and delivery to improve protective immunity against TB.

Source: npj Vaccines

DOI: 10.1038/s41541-026-01566-x

Authors: Elizabeth H. Chan, Hannah J. Lukeman, Claudio Counoupas, James A. Triccas

Institutions: The University of Sydney, Centenary Institute

Language: English

Topic: Tuberculosis Research and Epidemiology

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,890