Year: 2026
Type: article
Abstract: Clinical Trial Centers (CTCs) manage complex multi-site trials under rising regulatory and operational demands. Traditional workflows are labor-intensive and error-prone. Existing AI handles narrow and siloed tasks. We introduce Agent System for TRial Automation (ASTRA), a proposed multi-agent CTC in which a central Coordinator Agent and site-level Agents orchestrate domain-specialized AI-agent teams under human supervision. In this framework, agents follow standard messaging using shared environments and a version-controlled knowledge base. This manuscript introduces ASTRA as a design framework and summarizes key implementation and regulatory challenges for this hybrid automation-plus-oversight model.
Source: npj Digital Medicine
Institutions: Weill Cornell Medicine, University of Gothenburg
Language: English
Subfield: Health Informatics
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $4,090
OpenAlex ID: W7204070174
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