Phage anti-defense genes targeting NAD + metabolism and DNA replication are associated with a broad host range against Klebsiella pneumoniae
Year: 2026
Type: article
Abstract: . Deletion of these genes collapsed the host spectrum from 109 strains to fewer than 10, significantly compromising antibacterial efficacy. The wild-type phage substantially improves survival in a mouse bacteremia model. Our study identifies candidate genetic factors associated with the broad host range phenotype, specifically targeting host immunity, and provides a new strategy for engineering therapeutic phages.
Source: Virulence
Language: English
Subfield: Ecology
Field: Environmental Science
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $2,557
Award: G6600927996
OpenAlex ID: W7204073920