Comparative immunogenicity of several inactivated influenza vaccines among healthcare workers in Hong Kong
Year: 2026
Type: preprint
Study design: Observational Study
Abstract: ABSTRACT We compared the immunogenicity of three licensed egg-based inactivated influenza vaccines, including TetrAnflu (Sinovac quadrivalent), Fluarix Tetra (GSK quadrivalent), and Vaxigrip (Sanofi trivalent), in adult healthcare workers in Hong Kong during the 2025/26 season. Age- and sex-matched recipients (n=30–40 per group) with paired pre- and post-vaccination sera were identified from an ongoing cohort. Hemagglutination-inhibition assays were performed against the egg-propagated 2025/26 vaccine reference strains. The three vaccines induced broadly comparable geometric mean fold-rises, post-vaccination geometric mean titers, proportions achieving titers ≥40, and seroconversion rates against vaccine strains. These real-world data support the interchangeability of the three products for seasonal influenza vaccination programs among healthcare workers. Brief summary We compared the immunogenicity of three licensed egg-based inactivated influenza vaccines among age- and sex-matched healthcare workers in Hong Kong. Antibody responses were broadly comparable, supporting their interchangeability for influenza vaccination programs.
Source: medRxiv
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funder: Health and Medical Research Fund
OpenAlex ID: W7204084422