Changes in Intestinal Microbiota Tracked Using Next-generation Sequencing Before and after Antimicrobial Administration: An Example of Short-bowel Syndrome
Year: 2026
Type: article
Abstract: Although patients with short bowel syndrome may receive antimicrobial therapy for complications associated with abnormal intestinal microbiota, no established criteria for target bacterial screening or antimicrobial susceptibility standards exist. As a result, antimicrobial therapy is often administered without a microbiological evaluation. However, this approach carries uncertainties and risks, as antimicrobials can alter the microbiota in undesirable ways. To address this issue, we administered antimicrobial therapy to a patient with short bowel syndrome associated with chronic metabolic acidosis and monitored the changes in the intestinal microbiota using next-generation sequencing. We report these findings as they provide new insights into short bowel syndrome.
Source: Internal Medicine
Authors: Jumpei Hasumi, Gaku Harata
Language: English
Topic: Gut microbiota and health
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W7204100025