Work

Apex-guided HIV vaccination: liposome-displayed Env trimers elicit PG9-like cross-neutralizing antibodies

Year: 2026

Type: article

Abstract: In a recent Nature study, Guenaga et al. demonstrated that sequential immunization with heterologous NFL-stabilized HIV envelope (Env) trimers displayed on liposomes elicited PG9-like apex-directed cross-neutralizing serum IgG responses in all six immunized rhesus macaques, with neutralization breadth reaching up to 70% across a diverse virus panel. 1 This work provides a structural and immunological proof-of-concept that rational multivalent Env trimer design can guide B-cell maturation toward broadly neutralizing antibodies targeting the glycan-shielded HIV Env apex.

Source: Signal Transduction and Targeted Therapy

DOI: 10.1038/s41392-026-02943-7

Authors: Eun-Ha Hwang, Jung Joo Hong

Institutions: Korea Research Institute of Bioscience and Biotechnology, Korea University of Science and Technology

Language: English

Topic: HIV Research and Treatment

Subfield: Virology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,790